Title

Integrated Clinico-pathological and treatment outcome analysis of extra-cranial malignant germ cell tumors in children and adolescents in India


Aim

To study the event free survival (EFS) and overall survival (OS) of children aged ≤ 18 years with malignant extra-cranial GCT in India and determine underlying risk factors affecting survival.


Eligibility Criteria

● Inclusion Criteria:

Children aged ≤ 18 years diagnosed with malignant extra-cranial GCT on the basis of histopathology and/ or elevated tumour markers.
Patients who received partial treatment in the participating centre would still be eligible as long as adequate details of treatment done outside the participating centre is available and follow-up was done.

● Exclusion Criteria:

Treatment records not available.
Relapsed GCT at presentation to the participating center (i.e. primary therapy was received elsewhere).


Outcome Measures

● Overall survival (OS): Survival at 3 years, using Kaplan Mayer survival analysis.
● Event free survival (EFS): Survival without any events (relapse, progression, death due to any cause, treatment abandonment, secondary malignancy) at 3 years.


Summary

Missing


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